The combination of vanilla, cacao, and chile was revered by numerous Mesoamerican cultures. The understanding of the synergy is incomplete, but it interacts with the endocannabinoid system while also being stimulating and improving blood flow. The nutmeg and mace contribute small amounts of hallucinogenic myristicin. Several ingredients add MAOIs and β-caryophyllene which further interact with neurotransmitters. Others contribute uplifting and calming terpenoids and flavonoids.